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Risks and Benefits of Antioxidant Therapy for Post-Traumatic Arthritis—Department of Veterans Affairs
10/01/08–09/30/11
Joseph A. Buckwalter, M.D., Principal Investigator
James A. Martin, Ph.D., Lei Ding, Ph.D., Prem S. Ramkrishnan, Ph.D.
Yuki Tochigi, Ph.D., Co-Investigators
 

Quantifying Fracture Severity Using a 3-D Puzzle Solving Approach—
NIH 1 R21 AR054015

07/01/2008–03/31/2010
Donald D. Anderson, Ph.D., Principal Investigator
J. Lawrence Marsh, M.D., Thomas D. Brown, Ph.D., Co-Investigators

Research  
Research  
 
 

Orthopaedic Biomechanics
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Andrew R. Willis, Ph.D., Principal Investigator on subaward to the University of North Carolina at Charlotte
 

Objective Assessment of Fracture-Associated Soft Tissue Injury Using CT-Based Texture Analysis—Orthopaedic Trauma Association
01/01/2008–03/31/2009
Donald D. Anderson, Ph.D., J. Lawrence Marsh, M.D., Principal Investigators

Thomas D. Brown, Ph.D., Investigator

Biomechanics of Total Hip Impingement & Dislocation—Department of Veterans Affairs

10/01/2007–09/30/2011
John J. Callaghan, M.D., Principal Investigator
Thomas D. Brown, Ph.D., H. John Yack, Ph.D., Co-Investigators
Thomas E. Baer, B.A., Douglas R. Pedersen, Ph.D., Investigator
 

New Approaches to Assess and Forestall Osteoarthritis in Injured Joints—NIH 5 P50 AR055533
09/10/2007–08/31/2012
Joseph A. Buckwalter, M.D., CORT Director
Thomas D. Brown, Ph.D., CORT Associate Director

Project 1: Cartilage Extracellular Matrix Fragments and Trauma-Induced Chondrolysis
Joseph A. Buckwalter, M.D., Principal Investigator
James A. Martin, Ph.D., Co-Principal Investigator
Gene A. Homandberg, Ph.D., Prem Ramakrishnan, Ph.D., Honjun Zheng, Ph.D., Investigators

Project 2: Acute Versus Chronic Mechanical Damage in the Etiology of Post-Traumatic OA
Todd O. McKinley, M.D., Principal Investigator
James A. Martin, Ph.D., M. James Rudert, Ph.D.,
Yuki Tochigi, M.D., Ph.D., Investigators

Project 3: Validation and Application of MRI Biomarkers in Assessing Articular Cartilage Health
Douglas R. Pedersen, Ph.D., Principal Investigator
Annunziato Amendola, M.D., Co-Principal Investigator
James A. Martin, Ph.D., Daniel R. Thedens, Ph.D.,
Glenn Williams, Ph.D., Investigators

 

Project 4: Quantifying Injury Severity to Assess the Risk for Post-Traumatic Osteoarthritis
J. Lawrence Marsh, M.D., Principal Investigator
Donald D. Anderson, Ph.D., Co-Principal Investigator

Administrative Core
Joseph A. Buckwalter, M.D., Director
Thomas D. Brown, Ph.D., Associate Director
Martha L. Gray, Ph.D., Walter Herzog, Ph.D.,
Jack L. Lewis, Ph.D., Stefan Lohmander, M.D., Ph.D.,
Carol Vonwald, R.N., Advisory Group
Stephen L. Hillis, Ph.D., Biostatistician
Lois A. Lembke, M.S., Grant Administrator

Biomechanics & Imaging Core
Thomas D. Brown, Ph.D., Principal Investigator
Thomas E. Baer, B.A., George Y. El-Khoury, M.D.,
Anneliese D. Heiner, Ph.D., M. James Rudert, Ph.D.,
Andrew R. Willis, Ph.D., Investigators

Tissue and Experimental Modeling Core
Yuki Tochigi, M.D., Ph.D., Principal Investigator
Douglas C. Fredericks, B.S., James A. Martin, Ph.D.,
M. James Rudert, Ph.D., Investigators
Annunziato Amendola, M.D., Thomas D. Brown, Ph.D.,
Michael G. Conzemius, D.V.M, Ph.D., Diplomate, A.C.V.S., Consultants

Local Biomechanics of Median Nerve Insult in Carpal Tunnel—NIH
09/07/2007–08/31/2011
Thomas D. Brown, Ph.D, Principal Investigator
Ericka A. Lawler, M.D., M. James Rudert, Ph.D., Daniel R. Thedens, Ph.D.,
Yuki Tochigi, M.D., Ph.D., Co-Investigators

 

Biomechanics of the Dysplastic Hip—NIH
07/01/2007–06/30/2012
Jeffrey A. Weiss, Ph.D., Principal Investigator
Christopher L. Peters, M.D., Co-Principal Investigator
Gerard Ateshian, Ph.D., Consultant
Thomas D. Brown, Ph.D., Subaward Principal Investigator
M. James Rudert, Ph.D., Thomas E. Baer, B.A., Subaward Investigators

 

Non-Invasive Assessment of Cartilage Health: A New Approach to T1-rho MRI—American Orthopaedic Society for Sports Medicine
04/01/2007–03/31/2009
Annunziato Amendola, M.D., Principal Investigator
Daniel R. Thedens, Ph.D., James A. Martin, Ph.D.,
Douglas R. Pedersen, Ph.D., Investigators

 

Three Dimensional Virtual Orthopaedic Reconstruction of Comminuted Fractures—University of Iowa Roy J. and Lucille A. Carver College of Medicine Roy J. Carver Charitable Trust Medical Research Initiative
02/01/200703/31/2009
Thomas D. Brown, Ph.D., Principal Investigator
Donald D. Anderson, Ph.D., Co-Investigator
Andrew R. Willis, Ph.D., Consultant

 

Articular Contact: Identifying Patients At Risk For Painful Knee Osteoarthritis—University of Iowa OVPR Biological Sciences Funding Program

02/01/2007–08/31/2008

Neil A. Segal, M.D., Principal Investigator

Donald D. Anderson, Ph.D., Co-Investigator

Morgan Brubaker, Research Assistant
Stephen L. Hillis, Ph.D., Consultant

 

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Development of an Animal Model of Human Intra-Articular Fracture—University of Iowa OVPR Biological Sciences Funding Program

02/01/2007–12/31/2008
Yuki Tochigi, Ph.D., Principal Investigator
James A. Martin, Ph.D., M. James Rudert, Ph.D., Investigators
Thomas D. Brown, Ph.D., Michael G. Conzemius, D.V.M., Ph.D.,
Diplomate A.C.V.S.,
Todd O. McKinley, M.D., Consultants

 

The Effects of Osteochondral Defects and Focal Resurfacing on Joint Contact Mechanics—Arthrosurface, Inc.

01/01/2007–12/31/2008

Annunziato Amendola, M.D., Principal Investigator

Donald D. Anderson, Ph.D., Yuki Tochigi, M.D., Ph.D., Co-Principal Investigators

Thomas D. Brown, Ph.D., Douglas R. Pedersen, Ph.D.,

M. James Rudert, Ph.D., Co-Investigators

Thomas E. Baer, B.A., Research Associate

 

Quantifying Intra-articular Fracture Severity as a Risk Factorfor Post-traumatic Osteoarthritis—World Arthrosis Organization
01/01/07–12/31/08
J. Lawrence Marsh, M.D., Principal Investigator
Donald D. Anderson, Ph.D., Co-Principal Investigator

Joseph A. Buckwalter, M.D., Investigator

 

Implant/Construct Interactions in the Biomechanics of Total Hip Dislocation—NIH

09/25/2006–08/31/2010

Thomas D. Brown, Ph.D., Principal Investigator

John J. Callaghan, M.D.,  Co-Investigator

Jeffrey A. Weiss, Ph.D., University of Utah, Co-Investigator

Douglas R. Pedersen, Ph.D., M. James Rudert, Ph.D.,

Yuki Tochigi, M.D., Ph.D., Investigators

 

Wear Analysis of Intervertebral Total Disc Replacements—NIH
10/01/2005–06/30/2010  
Thomas D. Brown, Ph.D., Principal Investigator
Richard M. Hall, Ph.D., John Fisher, Ph.D., Eileen Ingham, Ph.D.,
Heinz-Michael Mayer, M.D., Ph.D., Sergio A. Mendoza, M.D.,
Douglas R. Pedersen, Ph.D., Co-Investigators

 

Pathogenesis–Prevention of Post-Traumatic OA—NIH
09/16/2002–08/31/2008
Joseph A. Buckwalter, M.D., SCOR Director
Thomas D. Brown, Ph.D., SCOR Co-Director

  • Project 1: Mechanical Determinants of Post-Traumatic OA
    09/16/2002–08/31/2008
    J.L. Marsh, M.D., Principal Investigator
    Donald D. Anderson, Ph.D., Thomas D. Brown, Ph.D.,
    George El-Khoury, M.D., Steven L. Hillis, Ph.D.,
    Todd O. McKinley, M.D., Douglas R. Pedersen, Ph.D., Investigators
    Joseph A. Buckwalter, M.D., Charles L. Saltzman, M.D., Consultants
     

  • Project 2: Effects of Distraction and Motion on Osteoarthritis
    09/16/2002–08/31/2008
    Annunziato Amendola M.D., Principal Investigator
    Thomas D. Brown, Ph.D., George El-Khoury, M.D.,
    Steven L. Hillis, Ph.D., James A. Martin, Ph.D.,
    M. James Rudert, Ph.D., Alan L. Stolpen, M.D., Ph.D.,
    Daniel R. Thedens, Ph.D., Investigators
     

  • Project 4: Oxidative Stress in Post-Traumatic OA
    09/16/2002–08/31/2008
    Joseph A. Buckwalter, M.D., Principal Investigator
    Anneliese D. Heiner, Ph.D., James A. Martin, Ph.D., Investigators
    Aloysius J. Klingelhutz, Ph.D., Collaborator
    Garry R. Buettner, Ph.D., Herbert Dircks, Consultants
     

  • Administrative and Biostatistics Core
    09/16/2002–08/31/2008
    Joseph A. Buckwalter, M.D., Principal Investigator
    Stephen L. Hillis, Ph.D., Investigator
    Lois A. Lembke, M.S., Grant Administrator
     

  • Biomechanics Core
    09/16/2002–08/31/2008
    Thomas D. Brown, Ph.D., Principal Investigator
    Donald D. Anderson, Ph.D., Investigator
    Douglas R. Pedersen, Ph.D., Investigator
    M. James Rudert, Ph.D., Investigator

KMI Universal Total Wrist Implant—Kinetikos Medical, Incorporated
03/31/1999–01/21/2009
Brian D. Adams, M.D., Principal Investigator

 

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  Department of Orthopaedics & Rehabilitation